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While we are addressing the quantification of clearance, note that the product of urine flow rate and urine concentration (numerator on the right-hand side of Equation 3-3) is excretion rate Therefore, we can also state that the clearance of substance X is the excretion rate divided by the plasma concentration Let us now examine the clearance of several substances that are important for the quantification of renal function, starting with inulin Inulin, as described previously, is a polysaccharide that is freely filtered and neither reabsorbed nor secreted All that is filtered is excreted Therefore, the volume of plasma cleared per unit time is the same as the glomerular filtration rate (GFR) (Figure 3 2) Inulin clearance is indeed the hallmark method for measuring GFR Why is inulin so good in this regard The first property is its filterability It moves into Bowman s space in the same proportion as the volume filtered Second, it cannot move in either direction by the paracellular route around the tubular epithelium The tight junctions are too restrictive to permit saccharides of any sort to move through them Third, there are no transport mechanisms either on the apical or basolateral surface of the tubular epithelium to take up inulin Finally, there are no enzymes (amylases) present in the tubular lumen to break down inulin Thus, it is freely filtered, and all that is filtered moves through the nephron into the urine Can something have a clearance greater than the GFR Indeed, yes One such substance is para-aminohippurate (PAH) This is a small (molecular weight of 194 Da) water-soluble organic anion that is freely filtered and also avidly secreted by the proximal tubule epithelium (via the transcellular route) The secretion rate is saturable (That is, there is a maximum rate of PAH secretion into the tubule Such tubular. rdlc ean 128 Packages matching GS1-128 - NuGet Gallery
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